Brentford aided their hopes of European qualification and handed a big blow to Spurs in the process with a comeback win in north London.
Spurs took the lead early in their final home game of the campaign as Harry Kane netted in his record 25th game of the league season when he curled home from 25 yards after a free-kick was laid into his path.
They almost added a second before the half-hour mark, only for Emerson Royal to be denied by some fine defending from Rico Henry before Ben Mee performed similar heroics to keep Heung-min Son at bay shortly before the break but after the interval, it all went wrong for the home side.
Five minutes after half-time, the visitors levelled as Bryan Mbeumo proved there can be life without Ivan Toney as he collected a pass on the right, cut inside, and curled low into the bottom corner.
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Eleven minutes later, he completed the turnaround by benefiting from a fantastic Aaron Hickey pass and producing another clinical finish to put the Bees in front.
And they made sure of the win with two minutes remaining when Oliver Skipp lost possession on the edge of his own area, allowing Mbeumo to feed the ball to Yoane Wissa in the centre of the area to beat Fraser Forster and put the seal on things.
With the win, Thomas Frank’s side close the gap no Tottenham in seventh to a single point.